Multiscale modelling of blood flow in health and disease Blood is a complex fluid: its properties emerge from physical and chemical interactions at the levels of proteins and cells. It is essential to account for the dynamics of these constituents for a mechanistic understanding of blood flow. In this talk I’ll present some models of blood flow that connect scales from molecules to cells to whole blood. As a case study, I will focus on sickle cell disease, in which aggregation of deoxygenated hemoglobin causes red blood cells to become stiffer; this can lead to vaso-occlusion of blood vessels and multiple pathologies. This article was published on 2025-04-22
