Understanding the drivers of antimicrobial resistance evolution The rise of antimicrobial resistance poses an increasingly serious threat to global public health and is becoming progressively more difficult to manage. The complexity of this challenge lies in the diverse mechanisms through which bacteria acquire resistance to antimicrobial treatments. In this talk, I will delve into the intricate dynamics of genetic, phenotypic, and mobile resistance mechanisms in microbial populations. will explore the conditions under which genetic or phenotypic resistance drives pathogen success and examine how this influences the mutational pathways that emerge in both chronic and acute infections. Further, I will discuss the genetic and environmental factors that shape the spread of mobile resistance elements in heterogeneous bacterial populations. Overall, I aim to emphasize the importance of studying mechanistic interactions in order to understand the complexity of microbial resistance dynamics. This article was published on 2025-04-22
