Signals of structural variation in reconstructed genealogies Following recent breakthroughs, it is now possible to reconstruct genome-wide genealogies from large-scale sequencing datasets, in the form of ancestral recombination graphs (ARGs): networks that connect sampled sequences through common ancestors, and capture the effects of the evolutionary forces that have shaped the observed genetic diversity. These developments have led to a surge of interest in developing powerful genealogy-based methods for the inference of evolutionary events and parameters. However, all currently available ARG reconstruction methods ignore the presence of genomic structural variants (SVs), a common and important type of mutation. I will give an overview of ARG reconstruction and ARG-based inference, and present new results on detecting the presence of SVs using reconstructed ARGs. This article was published on 2025-04-22
